- Paʻi ʻia ma ka Manaʻo Kūikawā
ʻO ka Lispro i lawelawe ʻia e ka QS-M needle-free injector i ka hopena o ka insulin mua a ʻoi aku ka kiʻekiʻe ma mua o ka peni maʻamau, a me kahi hopena hoʻohaʻahaʻa glucose mua me ka mana like like.
Pahuhopu: ʻO ka pahuhopu o kēia haʻawina ʻo ia ka loiloi i ka pharmacokinetic and pharmacodynamic (PK-PD) profiles o lispro i lawelawe ʻia e ka QS-M needle-free jet injector ma nā kumuhana Kina.
Hoʻolālā noiʻi a me nā ʻano hana: Ua hana ʻia kahi haʻawina hoʻopaʻa ʻia, pālua-makapō, pālua-dummy, cross-over.He ʻumikūmāwalu mau kānaka ola olakino i kiʻi ʻia.Ua lawelawe ʻia ʻo Lispro (0.2 units / kg) e ka QS-M needle-free jet injector a i ʻole ma ka peni maʻamau.Ua hana ʻia nā hoʻokolohua euglycemic clamp ʻehiku mau hola.He ʻumikūmāwalu mau mea manawaleʻa (ʻeiwa kāne a ʻeiwa wahine) i hoʻopaʻa ʻia ma kēia haʻawina.ʻO nā pae hoʻohui i hoʻokomo ʻia: ka poʻe nonsmokers 18-40 makahiki, me ka helu kino kino (BMI) o 17-24 kg / m2;nā kumuhana me nā hoʻokolohua biochemical maʻamau, ke koko, a me ka electrocardiograph;nā kumuhana i pūlima i ka ʻae ʻike.ʻO nā pae hoʻokae ʻia ʻo: nā poʻe me ka maʻi maʻi insulin a i ʻole nā moʻolelo maʻi ʻē aʻe;nā maʻi me nā maʻi maʻi mau e like me ka maʻi diabetes, nā maʻi cardiovascular, ate a i ʻole ka maʻi maʻi.Ua kāpae ʻia nā kumuhana i hoʻohana i ka waiʻona.Ua ʻae ʻia ke aʻo ʻana e ke Kōmike Ethics o ka Halemai Hoʻohui mua o Chongqing Medical University.
Nā hualoaʻa: Ua ʻike ʻia kahi ʻāpana nui ma lalo o ka pihi (AUC) o ka ʻike ʻana o ka insulin a me ka glucose infusion rate (GIR) i nā minuke 20 mua ma hope o ka hoʻokomo ʻia ʻana o lispro e ka jet injector i hoʻohālikelike ʻia me ka peni insulin (24.91 ± 15.25 vs. 12.52 ± 7.60 mg. . kg−1, P <0.001 no AUCGIR,0–20 min; 0.36 ± 0.24 vs. 0.10 ± 0.04 U min L−1, P <0.001 no AUCINS, 0–20 min).Ua hōʻike ʻia ke ʻano o ka needle-free i ka manawa pōkole e hiki ai i ka nui o ka insulin (37.78 ± 11.14 vs. 80.56 ± 37.18 min, P <0.001) a me GIR (73.24 ± 29.89 vs. 116.18 ± 51.89 min, P = 0.06).ʻAʻohe ʻokoʻa o ka hōʻike ʻana i ka insulin a me nā hopena hypoglycemic ma waena o nā mea ʻelua.Ka hopena: ʻO Lispro i lawelawe ʻia e ka QS-M needle-free injector ka hopena ma mua a ʻoi aku ka kiʻekiʻe o ka insulin ma mua o ka peni maʻamau, a me ka hopena hoʻohaʻahaʻa glucose mua me ka mana like like.
Ka manawa hoʻouna: Apr-29-2022